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Synthesis 2022; 54(10): 2457-2463
DOI: 10.1055/s-0041-1737412
DOI: 10.1055/s-0041-1737412
paper
Dichlorination of β-Keto Esters and 1,3-Diketones Mediated by Oxone/Aluminum Trichloride Mixture in Aqueous Medium
This work was supported by the Special Account for Research Funds of University of Crete (KA 10646, SARF UoC).
This work is dedicated to Professor G. J. Karabatsos on the occasion of his 90th birthday
Abstract
A new method for the α,α-dichlorination of β-keto esters using Oxone/aluminum trichloride mixture in aqueous medium has been developed. This useful process has also been applied successfully for the dichlorination of 1,3-diketones. The dichlorinated compounds have been produced in one step, high yields, and short reaction times.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0041-1737412.
- Supporting Information
Publication History
Received: 02 January 2022
Accepted after revision: 02 March 2022
Article published online:
07 April 2022
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